The protagonist, Takagi Saku, is approached by his estranged childhood friend, Hiragishi Shoko. She confesses that she suffers from a rare disease that causes her to become sexually aroused in response to any everyday movement. To cure the disease, she must take a special medicine and continue to release a set amount of arousal fluid within the effective time. In other words, she must continue to climax. She asks the protagonist to help her... Thus, the boy ends up making his beloved childhood friend "cum" all night long in a rental house in the suburbs ...